BubR1 shows self-control

Drebrin shows self-restraint

Injured neurons pump up the volume A wounded axon sends out a long-distance distress signal. HuntworkRodriguez et al. uncovered a positive feedback loop that might amplify the alarm and help it spread along the axon. A damaged axon dispatches an alert to the cell body, which fi res up genes that— depending on the neuron’s location—trigger healing or cause the axon to degenerate and the cell to ...

BubR1 and brain aging

BubR1 checks in with CENP-E

kinetochore protein plays both sides of the checkpoint field, according to Weaver et al. on page 551. They show that CENP-E, a mitotic checkpoint-silencing protein, also stimulates the amount of checkpoint inhibitor released from an unattached kinetochore. The mitotic checkpoint is the major mechanism preventing chromosomal loss during mammalian mitosis. Unattached kinetochores generate an inhi...

The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1

The E2F1, E2F2, and E2F3a transcriptional activators control proliferation. However, how the E2F activators regulate mitosis to maintain genomic integrity is unclear. Centrosome amplification (CA) and unregulated spindle assembly checkpoint (SAC) are major generators of aneuploidy and chromosome instability (CIN) in cancer. Previously, we showed that overexpression of single E2F activators indu...

BUBR1 deficiency results in abnormal megakaryopoiesis.

The physiologic function of BUBR1, a key component of the spindle checkpoint, was examined by generating BUBR1-mutant mice. BUBR1(-/-) embryos failed to survive beyond day 8.5 in utero as a result of extensive apoptosis. Whereas BUBR1(+/-) blastocysts grew relatively normally in vitro, BUBR1(-/-) blastocysts exhibited impaired proliferation and atrophied. Adult BUBR1(+/-) mice manifested spleno...